Systematic (IUPAC) name
N-[1-[2-(4-ethyl-5-oxo-1,4-dihydrotetrazol-1-yl)ethyl]-
4-(methoxymethyl)-4-piperidyl]-N-phenyl-propanamide
Identifiers: CAS number 71195-58-9; ATC code N01AH02; PubChem 189496
DrugBank APRD00726.
Chemical data: Formula C21H32N6O3; Mol. mass 416.517 g/mol
Physical data: Melt. point 140.8 °C (285 °F).
Pharmacokinetic data: Bioavailability Not applicable; Protein binding 92%
Metabolism Hepatic; Half life 90–111 minutes; Excretion ?
Therapeutic considerations: Pregnancy cat. ?; Legal status Schedule II(US)
Routes Intravenous.
Alfentanil (trade name Alfenta) is a potent but short-acting synthetic opioid analgesic drug, used for anaesthesia in surgery. It is an analogue of fentanyl with 10-20% the potency of fentanyl. It is an OP3 mu-agonist.
While alfentanil tends to cause less cardiovascular complications than other similar drugs such as fentanyl and remifentanil it tends to give stronger respiratory depression and so requires careful monitoring of breathing and vital signs. Alfentanil is administered by the parenteral (injected) route for fast onset of effects and precise control of dosage.
Alfentanil is a restricted drug which is classified as Schedule II in the USA, according to the U.S. DEA website.
Alfentanil was discovered at Janssen Pharmaceutica in 1976.
While alfentanil tends to cause less cardiovascular complications than other similar drugs such as fentanyl and remifentanil it tends to give stronger respiratory depression and so requires careful monitoring of breathing and vital signs. Alfentanil is administered by the parenteral (injected) route for fast onset of effects and precise control of dosage.
Alfentanil is a restricted drug which is classified as Schedule II in the USA, according to the U.S. DEA website.
Alfentanil was discovered at Janssen Pharmaceutica in 1976.
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